By Andrew Young
Deciphers amylin's body structure and divulges formerly unrecognized mechanisms primary to regulate bodyweight and gas homeostasis. additionally discusses healing application of amylin because the first new medication to regard diabetes considering that insulin.
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Extra info for Amylin: Physiology and Pharmacology
Despite pharmacological evidence of amylin sensitivity in several peripheral tissues, selective amylin binding outside of the brain is observed only in the renal cortex. The newly designated amylinomimetic drug class was defined on the basis of its unique pharmacology prior to the molecular characterization of amylin receptors. Currently, the class includes any agent that acts as an agonist at characterized amylin receptors. Several peptides, typically analogs of truncated salmon calcitonin, have been developed as potent and selective amylin antagonists and have been useful in identifying amylinergic responses.
Kolterman, O. , and Koda, J. E. (1996). Amylin response following Sustacalw ingestion is diminished in type II diabetic patients treated with insulin. Diabetologia 39, A149. Tissue Expression and Secretion of Amylin 39 Foster, G. , Clark, M. , Nathanson, B. , and Glass, H. I. (1972). Metabolic fate of human calcitonin in the dog. In ‘‘Endocrinology 1971’’ (S. ), pp. 72–78. Heinemann Books, London. Gilbey, S. , Ghatei, M. , Jones, P. , and Bloom, S. R. (1991). Islet amyloid polypeptide: Production by an osteoblast cell line and possible role as a paracrine regulator of osteoclast function in man.
Young, A. , Koda, J. , Tulp, O. , Johnson, M. , and Cooper, G. J. (1992). Hyperamylinemia, hyperinsulinemia, and insulin resistance in genetically obese LA/N‐cp rats. Hypertension 19, I101–I109. , and Luskey, K. (1990). Pancreatic beta cell expression of amylin in streptozotocin‐induced diabetes in rats. Diabetes 39, 143A. , Ghatei, M. , and Bloom, S. R. (1990). Islet amyloid polypeptide‐like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin. J. Endocrinol. 126, 425–429.